Global Registry for Inherited Neuropathies


Pain and Charcot-Marie-Tooth – Is there a role for Magnesium?

Occasionally you will hear someone say that X helps disease Y and “you should try it”. X could be something as simple as a supplement and Y could represent a major disease like Charcot-Marie-Tooth (CMT). We cannot stress strongly enough that it is important not take anything without first consulting a healthcare professional. CMT is no exception, regardless of how apparently mundane that proposed treatment may be it is not worth the risk.

Here at HNF, we have had recent exchanges of emails with two patients who were magnesium deficient. According to their description, their lives changed dramatically after adding magnesium supplements to their diets. I decided I needed to explore the science on what was known with a broad inherited neuropathy audience.

First, I searched PubMed to see if there were any scientific studies that had been conducted specifically on the effects of magnesium on CMT.  Unfortunately no papers were found.  I then searched to see if a correlation had been made with CMT and magnesium deficiency. Again, no such correlation has been published as far as I can tell. Clearly it makes you wonder whether anyone has explored the role of magnesium for CMT and just not published it. If there are any scientists reading this that can shed any light please let us know.

Magnesium has however been tested for neuropathic pain and the authors describedthat magnesium diminished the frequency of pain paroxysms and improved the emotional component of behavior in patients suffering from neuropathic pain.” But they also suggested “the clinical trial displayed a large placebo response and could not demonstrate any significant difference in pain alleviation after a month of oral treatment between magnesium and placebo”.

In simple terms magnesium did not work for neuropathic pain.

If you have CMT or any form of inherited neuropathy and had any mineral deficiencies that required treatment, that in turn impacted your underlying disease, please let us know by sending an email to: This e-mail address is being protected from spambots. You need JavaScript enabled to view it